Hazardous Materials

Section 1: Identification

Name: HEPARIN

MEDICATION
MEDICATION (VET)

Section 2: Hazard(s) Identification

Signal Word(s): Warning

Section 3: Composition/Information on Ingredients

Name: HEPARIN

CAS Registry Number: 9005-49-6

UNII: T2410KM04A

DEPO-HEPARIN[U.S. Department of Health, Education & Welfare, Public Health Service. Center for Disease Control, National Institute for Occupational Safety & Health. Registry of Toxic Effects of Chemical Substances. 1978 edition. Washington, DC: U.S. Government Printing Office, 1979., p. 617]
HED-HEPARIN[U.S. Department of Health, Education & Welfare, Public Health Service. Center for Disease Control, National Institute for Occupational Safety & Health. Registry of Toxic Effects of Chemical Substances. 1978 edition. Washington, DC: U.S. Government Printing Office, 1979., p. 617]
ALPHA-HEPARIN
HEPARINATE[U.S. Department of Health, Education & Welfare, Public Health Service. Center for Disease Control, National Institute for Occupational Safety & Health. Registry of Toxic Effects of Chemical Substances. 1978 edition. Washington, DC: U.S. Government Printing Office, 1979., p. 617]
HEPARINIC ACID
HEPARIN SULFATE
HEPATHROM[U.S. Department of Health, Education & Welfare, Public Health Service. Center for Disease Control, National Institute for Occupational Safety & Health. Registry of Toxic Effects of Chemical Substances. 1978 edition. Washington, DC: U.S. Government Printing Office, 1979., p. 617]
LIPO-HEPIN[U.S. Department of Health, Education & Welfare, Public Health Service. Center for Disease Control, National Institute for Occupational Safety & Health. Registry of Toxic Effects of Chemical Substances. 1978 edition. Washington, DC: U.S. Government Printing Office, 1979., p. 617]
LIQUAEMIN[U.S. Department of Health, Education & Welfare, Public Health Service. Center for Disease Control, National Institute for Occupational Safety & Health. Registry of Toxic Effects of Chemical Substances. 1978 edition. Washington, DC: U.S. Government Printing Office, 1979., p. 617]
LIQUEMIN[U.S. Department of Health, Education & Welfare, Public Health Service. Center for Disease Control, National Institute for Occupational Safety & Health. Registry of Toxic Effects of Chemical Substances. 1978 edition. Washington, DC: U.S. Government Printing Office, 1979., p. 617]
PULARIN[U.S. Department of Health, Education & Welfare, Public Health Service. Center for Disease Control, National Institute for Occupational Safety & Health. Registry of Toxic Effects of Chemical Substances. 1978 edition. Washington, DC: U.S. Government Printing Office, 1979., p. 617]
SUBLINGULA
THROMBOLIQUINE[U.S. Department of Health, Education & Welfare, Public Health Service. Center for Disease Control, National Institute for Occupational Safety & Health. Registry of Toxic Effects of Chemical Substances. 1978 edition. Washington, DC: U.S. Government Printing Office, 1979., p. 617]
VETREN

Section 4: First-Aid Measures

Section 5: Fire-Fighting Measures

Water spray, dry chemical, carbon dioxide or foam as appropriate for surrounding fire and materials. /Heparin Sodium/[United States Pharmacopeial Convention, Inc (USP); MSDS Database Online; Material Safety Data Sheet: Heparin Sodium; Catalog Number: 1304038; (Revision Date: May 5, 2008)]

As with all fires, evacuate personnel to a safe area. Firefighters should use self-contained breathing equipment and protective clothing. /Heparin Sodium/[United States Pharmacopeial Convention, Inc (USP); MSDS Database Online; Material Safety Data Sheet: Heparin Sodium; Catalog Number: 1304038; (Revision Date: May 5, 2008)]

Section 6: Accidental Release Measures

Wear approved respiratory protection, chemically compatible gloves and protective clothing. Wipe up spillage or collect spillage using a high efficiency vacuum cleaner. Avoid breathing dust. Place spillage in appropriately labeled container for disposal. Wash spill site. /Heparin Sodium/[United States Pharmacopeial Convention, Inc (USP); MSDS Database Online; Material Safety Data Sheet: Heparin Sodium; Catalog Number: 1304038; (Revision Date: May 5, 2008)]

Section 7: Handling and Storage

Engineering controls such as exhaust ventilation are recommended. /Heparin Sodium/[United States Pharmacopeial Convention, Inc (USP); MSDS Database Online; Material Safety Data Sheet: Heparin Sodium; Catalog Number: 1304038; (Revision Date: May 5, 2008)]
Use a NIOSH approved respirator, if it is determined to be necessary by an industrial hygiene survey involving air monitoring. In the event that a respirator is not required, an approved dust mask should be used. /Heparin Sodium/[United States Pharmacopeial Convention, Inc (USP); MSDS Database Online; Material Safety Data Sheet: Heparin Sodium; Catalog Number: 1304038; (Revision Date: May 5, 2008)]

Section 8: Exposure Controls/Personal Protection

Section 9: Physical and Chemical Properties

White or pale-colored amorphous powder[Lewis, R.J. Sr.; Hawley's Condensed Chemical Dictionary 15th Edition. John Wiley & Sons, Inc. New York, NY 2007., p. 638]

Nearly odorless[Lewis, R.J. Sr.; Hawley's Condensed Chemical Dictionary 15th Edition. John Wiley & Sons, Inc. New York, NY 2007., p. 638]

Mol weight varies from 6000-20,000 Daltons[O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 2006., p. 804]

Soluble in water; insoluble in alcohol, benzene, acetone, chloroform, and ether[Lewis, R.J. Sr.; Hawley's Condensed Chemical Dictionary 15th Edition. John Wiley & Sons, Inc. New York, NY 2007., p. 638]

Specific optical rotation: +55 deg at 20 deg C/D[O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 2006., p. 804]

The molecular mass is in the range of 6,000 and 30,000 (average 12,000) depending on the origin.[Kleemann A; Ullmann's Encyclopedia of Industrial Chemistry. 7th ed. (2008). New York, NY: John Wiley & Sons; Cardiovascular Drugs. Online Posting Date: 15 Jan 2008]

Heparin is strongly acidic because of its content of covalently linked sulfate and carboxylic acid groups.[FDA; RxList. The Internet Drug Index. Top 200 Drugs - US Only. Available from, as of Sept 29, 2010: http://www.rxlist.com/script/main/hp.asp]

DUE TO PRESENCE OF NUMEROUS IONIZABLE SULFATE GROUPS MOLECULE POSSESSES STRONG ELECTRONEGATIVE CHARGE[Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 568]

Soluble in water; insoluble in organic solvents /Heparin magnesium salt/[O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 2006., p. 804]

White to grayish-brown amorphous powder; odorless; hygroscopic; specific optical rotation: +47 deg at 25 deg C/D (water, 1.5%); soluble in saline solution; practically insoluble in alcohol, acetone, benzene, ether, chloroform. pH of 1% aqueous solution = 6.0-7.5 /Heparin sodium salt/[O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 2006., p. 804]

Soluble in water /Heparin sodium/[Lewis, R.J. Sr. (ed) Sax's Dangerous Properties of Industrial Materials. 11th Edition. Wiley-Interscience, Wiley & Sons, Inc. Hoboken, NJ. 2004., p. V3: 1900]

IT WILL NOT DIALYZE THROUGH PARCHMENT MEMBRANE, & ONLY SLIGHTLY THROUGH COLLODION MEMBRANE /SODIUM SALT/[Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 766]

Formula of (C12H16NS2Na3)20 and mol wt of 12,000 have been suggested for sodium heparinate /Sodium heparinate/[Lewis, R.J. Sr.; Hawley's Condensed Chemical Dictionary 15th Edition. John Wiley & Sons, Inc. New York, NY 2007., p. 638]

Has the highest negative charge density of any known biological molecule[Wishart DS et al; DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. Available from, as of Sept 28, 2010: http://www.drugbank.ca]

Section 10: Stability and Reactivity

Hygroscopic; ampuled solution may be stored at room temperature for at least 12 months /Sodium salt/[O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 2006., p. 805]

Section 11: Toxicological Information

All references are peer reviewed