Hazardous Materials

Section 1: Identification

Name: Flibanserin

MEDICATION

Section 2: Hazard(s) Identification

Signal Word(s): Warning

Section 3: Composition/Information on Ingredients

Name: Flibanserin

CAS Registry Number: 167933-07-5

UNII: 37JK4STR6Z

1,3-Dihydro-1-(2-(4-(3-(trifluoromethyl)phenyl)-1-piperazinyl)ethyl)-2H-benzimidazol-2-one[National Library of Medicine, SIS; ChemIDplus Lite Record for Flibanserin (167933-07-5). Available from, as of October 8, 2015: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp]
1-(2-(4-(3-Trifluoromethylphenyl)piperazin-1-yl)ethyl)benzimidazol(1H)-2-one[National Library of Medicine, SIS; ChemIDplus Lite Record for Flibanserin (167933-07-5). Available from, as of October 8, 2015: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp]
1-(2-(4-(alpha,alpha,alpha-Trifluoro-m-tolyl)-1-piperazinyl)ethyl)-2-benzimidazolinone[National Library of Medicine, SIS; ChemIDplus Lite Record for Flibanserin (167933-07-5). Available from, as of October 8, 2015: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp]
UNII-37JK4STR6Z[National Library of Medicine, SIS; ChemIDplus Lite Record for Flibanserin (167933-07-5). Available from, as of October 8, 2015: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp]
Girosa[National Library of Medicine, SIS; ChemIDplus Lite Record for Flibanserin (167933-07-5). Available from, as of October 8, 2015: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp]
Female Viagra [Street Name][National Library of Medicine, SIS; ChemIDplus Lite Record for Flibanserin (167933-07-5). Available from, as of October 8, 2015: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp]
BIMT 17 BS[National Library of Medicine, SIS; ChemIDplus Lite Record for Flibanserin (167933-07-5). Available from, as of October 8, 2015: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp]
Bimt 17[National Library of Medicine, SIS; ChemIDplus Lite Record for Flibanserin (167933-07-5). Available from, as of October 8, 2015: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp]
Bimt-17[National Library of Medicine, SIS; ChemIDplus Lite Record for Flibanserin (167933-07-5). Available from, as of October 8, 2015: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp]
Addyi[National Library of Medicine, SIS; ChemIDplus Lite Record for Flibanserin (167933-07-5). Available from, as of October 8, 2015: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp]

Section 4: First-Aid Measures

Section 5: Fire-Fighting Measures

Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.[Sigma-Aldrich; Material Safety Data Sheet for Flibanserin, Product Number: SML0797, Version 5.2 (Revision Date 05/26/2014). Available from, as of November 03, 2015: http://www.sigmaaldrich.com/safety-center.html]

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.[Sigma-Aldrich; Material Safety Data Sheet for Flibanserin, Product Number: SML0797, Version 5.2 (Revision Date 05/26/2014). Available from, as of November 03, 2015: http://www.sigmaaldrich.com/safety-center.html]

Section 6: Accidental Release Measures

Accidental Release Measures. Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.[Sigma-Aldrich; Material Safety Data Sheet for Flibanserin, Product Number: SML0797, Version 5.2 (Revision Date 05/26/2014). Available from, as of November 03, 2015: http://www.sigmaaldrich.com/safety-center.html]

Section 7: Handling and Storage

Respiratory protection: Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N99 (US) or type P2 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).[Sigma-Aldrich; Material Safety Data Sheet for Flibanserin, Product Number: SML0797, Version 5.2 (Revision Date 05/26/2014). Available from, as of November 03, 2015: http://www.sigmaaldrich.com/safety-center.html]
Body Protection: Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace[Sigma-Aldrich; Material Safety Data Sheet for Flibanserin, Product Number: SML0797, Version 5.2 (Revision Date 05/26/2014). Available from, as of November 03, 2015: http://www.sigmaaldrich.com/safety-center.html]
Skin protection: Handle with gloves.[Sigma-Aldrich; Material Safety Data Sheet for Flibanserin, Product Number: SML0797, Version 5.2 (Revision Date 05/26/2014). Available from, as of November 03, 2015: http://www.sigmaaldrich.com/safety-center.html]

Section 8: Exposure Controls/Personal Protection

Section 9: Physical and Chemical Properties

White, to off-white powder[US NLM; DailyMed. Current Medical Information. US Natl Lib Med, Natl Inst Health, Health Human Serv. Available from, as of Oct 15, 2015: http://dailymed.nlm.nih.gov/dailymed/about.cfm]

390.41[O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013., p. 752]

log Kow = 3.41 (est)[US EPA; Estimation Program Interface (EPI) Suite. Ver. 4.1. Nov, 2012. Available from, as of Oct 15, 2015: http://www.epa.gov/oppt/exposure/pubs/episuitedl.htm]

In water, 4.312 mg/L at 25 deg C (est)[US EPA; Estimation Program Interface (EPI) Suite. Ver. 4.1. Nov, 2012. Available from, as of Oct 15, 2015: http://www.epa.gov/oppt/exposure/pubs/episuitedl.htm]

Insoluble in water[US NLM; DailyMed. Current Medical Information. US Natl Lib Med, Natl Inst Health, Health Human Serv. Available from, as of Oct 15, 2015: http://dailymed.nlm.nih.gov/dailymed/about.cfm]

Sparingly soluble in methanol, ethanol, acetonitrile, toluene; solulble in acetone; freely soluble in chloroform; very soluble in methylene chloride[US NLM; DailyMed. Current Medical Information. US Natl Lib Med, Natl Inst Health, Health Human Serv. Available from, as of Oct 15, 2015: http://dailymed.nlm.nih.gov/dailymed/about.cfm]

3.13X10-10 mm Hg at 25 deg C (est)[US EPA; Estimation Program Interface (EPI) Suite. Ver. 4.1. Nov, 2012. Available from, as of Oct 15, 2015: http://www.epa.gov/oppt/exposure/pubs/episuitedl.htm]

Crystals from isopropanol; MP 230-231 deg C/Filbanserin hydrochloride/[O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013., p. 752]

SMILES C(F)(F)(F)c1cc(N2CCN(CCN3c4c(cccc4)NC3=O)CC2)ccc1[US EPA; Estimation Program Interface (EPI) Suite. Ver. 4.1. Nov, 2012. Available from, as of Oct 15, 2015: http://www.epa.gov/oppt/exposure/pubs/episuitedl.htm]

Henry's Law constant = 4.03X10-14 ctm-cu m/mol at 25 deg C (est)[US EPA; Estimation Program Interface (EPI) Suite. Ver. 4.1. Nov, 2012. Available from, as of Oct 15, 2015: http://www.epa.gov/oppt/exposure/pubs/episuitedl.htm]

Section 10: Stability and Reactivity

Incompatible materials: Strong oxidizing agents[Sigma-Aldrich; Material Safety Data Sheet for Flibanserin, Product Number: SML0797, Version 5.2 (Revision Date 05/26/2014). Available from, as of November 03, 2015: http://www.sigmaaldrich.com/safety-center.html]

Stable under recommended storage conditions.[Sigma-Aldrich; Material Safety Data Sheet for Flibanserin, Product Number: SML0797, Version 5.2 (Revision Date 05/26/2014). Available from, as of November 03, 2015: http://www.sigmaaldrich.com/safety-center.html]

Section 11: Toxicological Information

All references are peer reviewed